Expert Perspectives: ESMO 2017 Changes Lung Cancer Practice Necessary cookies enable core functionality. Several methods have been developed to prevent carboplatin-related hypersensitivity reactions (Libra et al., 2003; Confino-Cohen et al., 2005; Gomez et al., 2009; Greene et al., 2010; Takase et al., 2015; Shah et al., 2016). Oncol. (2012) demonstrated that carboplatin treatment can be continued successfully in patients whose hypersensitivity reactions are managed in a timely fashion. The MASCC/ESMO guidelines recommend that patients receiving HEC are given a dose of 20 mg dexamethasone on Day 1 to prevent acute emesis; however, if the NK 1 RAs aprepitant or netupitant are also used, a reduced dose of 12 mg dexamethasone is recommended. 2018 Oct 1;29(Suppl 4):iv260. The symptoms and signs of the 75 women with carboplatin-related hypersensitivity reactions are given in Table 4. Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Chan. Close monitoring is warranted for patients with a history of drug or food allergy, malignant ascites, or cumulative carboplatin dose >4,000 mg. Strategies for preventing carboplatin-related hypersensitivity include reducing the carboplatin infusion rate and employing desensitization protocols with anti-allergy medications. Via Ginevra 4, 6900 Lugano - CH Copyright 2023 European Society for Medical Oncology All rights reserved worldwide. Int. Monitor. Please enable it to take advantage of the complete set of features! However, basophil activation has been observed in patients with a history of severe carboplatin hypersensitivity reaction (Iwamoto et al., 2014). Model of in vitro mouse mast cells activation and desensitization. A., Colombo, N., du Bois, A., Delaloye, J. F., Kristensen, G. B., et al. Patients who previously received platinum compounds were excluded. Cancer. Gynecol. ESMO is a Swiss-registered not-for-profit organisation. Yamamoto A, Kamoi S, Matsuda S, Kawase R, Nakanishi K, Suzuki S. Medicines (Basel). desensitization; drug allergy; monoclonal antibodies in cancer; platins; taxanes. Drug allergy is a rising problem in the twenty-first century which affects all populations and races, children, and adults, and for which the recognition, diagnosis, management, and treatment is still not well standardized. The ESMO Clinical Practice Guidelines (CPGs) are intended to provide the user with a set of recommendations for the best standards of cancer care, based on the findings of evidence-based medicine. Annals of Oncology (2021) 32 (suppl_5): S407-S446. This site uses cookies. The incidence of carboplatin-related hypersensitivity correlated with cycle number and dose, with the first episode occurring at a median of 12 cycles and 6,816 mg. The essential content of the guidelinesin condensed slide format in PDF or PowerPoint. The PAGA project aims to adapt the ESMO Clinical Practice Guidelines by integrating Asian ethnic, scientific, socioeconomic, and local practice characteristics. doi: 10.2217/imt.14.71, Chiang, Y. C., Chen, C. A., Chiang, C. J., Hsu, T. H., Lin, M. C., You, S. L., et al. Educate. doi: 10.1016/j.ygyno.2016.09.027, Bruchim, I., Goldberg, A., Fishman, A., and Confino-Cohen, R. (2014). The site is secure. Gynecol. 2017 Jul 1;28(suppl_4):iv100-iv118. Atopic patients are at increased risk for chemotherapy and MoAbs drug allergy and the current patterns of treatment with recurrent and intermittent drug exposures may favor the development of drug allergies. Critical revision: C-AC. van de Loosdrecht, Arjan A. The incidence of carboplatin hypersensitivity ranges from 8 to 11% (Libra et al., 2003; Confino-Cohen et al., 2005; Schwartz et al., 2007; Koshiba et al., 2009). Drug Hypersensitivity and Desensitizations: Mechanisms and New Approaches. Gynecol. ESMO is a Swiss-registered not-for-profit organisation. Necessary cookies enable core functionality. Bookshelf also successfully developed a platinum desensitization protocol for patients with either a positive carboplatin skin test or a history of prior carboplatin hypersensitivity (Altwerger et al., 2017). The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. The ESMO Expert Consensus Statement series of publications contain recommendations on well-defined, controversial or clinically relevant topics and are produced by 20-40 key experts in the field. WHIPPANY, N.J., Sept. 1, 2017 /PRNewswire/ -- Bayer will present the latest research from across its growing oncology portfolio at the European Society for Medical Oncology (ESMO) 2017 Congress . 4 - 9 Without premedication, hypersensitivity reactions (HSRs) occurred in 25%-30% of patients in these studies and clinical development of paclitaxel was consequently delayed. Allergy in Cancer Care: Antineoplastic Therapy-Induced Hypersensitivity Reactions. In our study, 36% of the patients with carboplatin-related hypersensitivity reactions had a history of drug allergies. It would be worthwhile to design a perspective trial that could randomize patients with carboplatin hypersensitivity to receive an alternative regimen without carboplatin. 2022 May 20;12:879391. doi: 10.3389/fonc.2022.879391. Median cycle and dose of carboplatin administered to women with or without hypersensitivity reactions. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. B., Phillips, P. C., Kang, T. I., et al. Desensitization is a high risk procedure in which a drug is administrated to a patient who has already presented an allergic reaction, almost always severe. Classical and new chemotherapy drugs, monoclonal antibodies (MoAbs), and small molecules to treat cancer and chronic inflammatory diseases are aimed at improving quality of life and life expectancy of patients, but an increasing number of reactions including anaphylaxis precludes their use in targeted populations. HHS Vulnerability Disclosure, Help We analyzed the incidence, characteristics, risk factors, management, and outcomes of carboplatin-related hypersensitivity reactions among these patients. J. Clin. A total of 59 women experienced mild signs and symptoms (grades 1 and 2), including skin rash (69.3%), skin itching (64.0%), facial flushing (56.0%), dyspnea (41.3%), chest pain (25.3%), tachycardia (18.7%), paresthesias (16.0%), abdominal cramping (13.3%), and diaphoresis (12.0%). Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly. MBC: CLEOPATRA (NCT00567190; PMID 22149875, 23602601, 25693012; 32171426), MetaPHER (NCT02402712; 33748921); EBC: APHINITY (NCT01358877; 28581356, 33539215), NeoSphere (NCT00545688; 22153890, 27179402), TRYPHAENA (NCT00976989; 23704196, 29223479), BERENICE (NCT02132949; 29253081, SABCS 2017 P5-20-04), FeDeriCa (NCT03493854; 33357420), PHranceSCa (NCT03674112; ESMO 2020 165MO). (2003) reported that paclitaxel with platinum improves overall survival compared to conventional platinum-based chemotherapy among patients with relapsed platinum-sensitive ovarian cancer. Table 6. Oncol. 28, 33233329. Open. J Oncol Pract. J. NCT00567190, NCT02402712, NCT01358877, NCT00545688, NCT00976989, NCT02132949, NCT03493854, NCT03674112. | DOI: 10.1097/HS9.0000000000000695. Cancer 104, 640643. Upon the occurrence of symptoms and signs, carboplatin infusion was immediately stopped. J Investig Allergol Clin Immunol. Monitor. Management of toxicities from immunotherapy: ESMO Clinical Practice Epub 2022 Nov 29. Symptoms and signs of hypersensitivity reactions amendable to desensitization. PMC Table 4. Most events occurred during chemotherapy. Oncol. Borrs Cuartero J, Farzanegan Miano R, Torres Gorriz MC, Germn Snchez A, Aznar RC, Raducan I, Castell Carrascosa JV, Sanchez Hernandez A, Enrique E. Front Allergy. Swain: Financial Interests, Personal, Advisory Role: AstraZeneca; Financial Interests, Personal, Advisory Role: Daiichi Sankyo; Financial Interests, Personal, Advisory Role: F. 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Characteristics of the 735 women receiving carboplatin-based chemotherapy. 2017 Jun 20;18(6):1316. doi: 10.3390/ijms18061316. Gerber, C. van den Hurk, P. Fernndez-Peas, D. Santini, F. Jahn, K. Jordanon behalf of the ESMO Guidelines Committee. doi: 10.1159/000055363, Pujade-Lauraine, E., Wagner, U., Aavall-Lundqvist, E., Gebski, V., Heywood, M., Vasey, P. A., et al. We further evaluated the median carboplatin cycle and dose administered to women with and without carboplatin-related hypersensitivity. . Carboplatin and other paltins such as cisplatin and oxaliplatin reactions include classical symptoms of anaphylaxis with cutaneous, respiratory, cardiovascular, and gastrointestinal symptoms. A Comprehensive Methodology to Systematically Identify Drug - Springer The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. 15, 780784. Immunotherapy 6, 905912. These patients were provided with intravenous fluid infusion and medications, including corticosteroids, antihistamines, and oxygen application. Za. The tests were analyzed at an accredited lab according to protocol. Putative mechanism of protection against anaphylaxis during human desensitizations. Cancer. S M S, Naveen NR, Rao GK, Gopan G, Chopra H, Park MN, Alshahrani MM, Jose J, Emran TB, Kim B. All of these reported symptoms and signs occurred within an hour of initiating carboplatin administration. Do Steroids Matter? A Retrospective Review of Premedication for Taxane The cumulative incidence of severe carboplatin-related hypersensitivity was 1% after 15 cycles and 2% after 24 cycles, with a plateau beyond this cycle number, and 1% at >7,500 mg and 2% at >12,500 mg, with a plateau beyond this dose (Figures 1A,B ). Oncol. Tyler T, Schultz A, Venturini A, Giuliano C, Bernareggi A, Spezia R, Voisin D, Stella V. Clin Pharmacol Drug Dev. Prior investigations reported that a history of drug allergies correlates with the incidence of carboplatin-related hypersensitivity reactions (Libra et al., 2003; Sliesoraitis and Chikhale, 2005). As shown in Table 6, drug or food history (odd ratios [OR] 2.340, 95% confidence interval [CI] 1.374-3.984, P = 0.0018), malignant ascites (OR 1.895, 95% CI 1.1083.241, P = 0.0196), and cumulative carboplatin dose (4,0004,999 mg: OR 5.507, 95% CI 1.79616.887, P = 0.0028; 5,0009,999 mg: OR 7.244, 95% CI 2.74019.149, P < 0.0001; 10,000 mg: OR 8.461, 95% CI 3.00723.806, P < 0.0001; P for trend < 0.0001) significantly positively correlated with carboplatin hypersensitivity. Hypersensitivity & Infusion Reaction Management Author: Updated 2.21.19 Subject: SCC Pharmacy In the majority of ovarian cancer cases, primary management entails surgical staging or cytoreduction, followed by systemic chemotherapy (Ledermann et al., 2013). LUGANO-MADRID, 09 September, 2017 -The preliminary results of a study to be presented at the ESMO 2017 Congress in Madrid (1) show that socio-psychological factors have become more significant for . Incidence of carboplatin-related hypersensitivity reactions in Japanese patients with gynecologic malignancies. Author Mariana Castells 1 Affiliation 1 Allergy and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States. 57 . We also recorded the procedures applied to treat the hypersensitivity reactions and efforts to manage the side effects of carboplatin administration. There is a need to further characterise risk of anaphylaxis/hypersensitivity with PH IV/PH FDC SC to support safe administration outside of clinics. Before Zhonghua. ESMO is a Swiss-registered not-for-profit organisation. Monitor. 10.1016/annonc/annonc687, Anaphylaxis and hypersensitivity in trials of intravenous pertuzumab + trastuzumab (PH IV) or the fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection (PH FDC SC) for HER2-positive breast cancer (BC), Targeted Therapies and Precision Oncology, Interpreting Oncological Study Publications, Cancer Diagnosis and Treatment Evaluation, Cancer Treatment in Special Clinical Situations, Clinical Pharmacology of Anti-Cancer Agents, Controversies in upper GI oncology: ESMO Open Podcasts, International Prognostic Index Tools for Lymphoma, Anti-Cancer Agents and Biological Therapy, Drug-Drug Interactions with Kinase Inhibitors, PARP inhibition and DNA Damage Response (DDR), Cancer Aetiology, Epidemiology and Prevention, Cancer in Special situations (pregnancy, young, elderly, hereditary), Multikinase Inhibitor-Related Skin Toxicity, Precision Medicine and Validated Biomarkers, ESMO Recommendations in Precision Medicine. doi: 10.1093/annonc/mdy158. MINIMAL Requirements:Google Chrome 24+,Mozilla Firefox 20+,Internet Explorer 11,Opera 1518,Apple Safari 7,SeaMonkey 2.15-2.23, Published in 2020 Ann Oncol (2020)Authors:M.E. Tamiya, M., Kuhara, H., Hirashima, T., Kondo, Y., Santo, M., Morishita, N., et al. Similarly, Kandel et al. 2011 Aug;12(8):806-14. doi: 10.1016/S1470-2045(10)70208-4. Statistical analyses were performed using the Statistical Package of Social Studies (SPSS) version 17.0 (SPSS, Inc., Chicago, IL) and SAS software version 9.4 (SAS Inc, NC, USA) for Windows. Disclaimer. Epub 2019 Jul 3. In Taiwan, carboplatin was first introduced for the treatment of ovarian cancer in 2004. 17, 11411145. J Exp Clin Cancer Res (2011) 30:93.10.1186/1756-9966-30-93 Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly. 'Allergy' is a hypersensitivity reaction (HSR) initiated by specic immunolo- gical mechanisms. Prevention and Management of Dermatological Toxicities Related - ESMO PDF Hypersensitivity & Infusion Reaction Management - Stephenson Cancer Center J. Gynecol. Infusion reactions to systemic chemotherapy - UpToDate Life expectancy for cancer patients allergic and desensitized to carboplatin and non-allergic to, MeSH ESMO Clinical Practice Guideline update on the use of systemic therapy DARMSTADT, Germany, August 31, 2017 /PRNewswire/ --Not intended for UK-based media Data to showcase Merck KGaA, Darmstadt, Germany's strong and d. Metrics. 2017;40(3):120-127. doi: 10.1159/000458443. 144, 7782. Pharmacol. doi: 10.1002/pbc.25697, Siegel, R. L., Miller, K. D., and Jemal, A. Challenges in the Development of Intravenous Neurokinin-1 Receptor Antagonists: Results of a Safety and Pharmacokinetics Dose-Finding, Phase1 Study of Intravenous Fosnetupitant. This was the largest series of gynecological malignancies investigated for carboplatin-related hypersensitivity reactions. Int. ESMO Call to Action on COVID-19 Vaccinations and Patients with Cancer: Vaccinate. Multivariate analyses of clinical parameters for carboplatin-related hypersensitivity reactions. Compared to women without hypersensitivity reactions, women who experienced hypersensitivity reactions had a significantly greater median cycle number (12 vs. 6, P < 0.001, independent sample t-test) and dose (6,816 vs. 3,844 mg, P < 0.001, independent sample t-test). A., Raja, F. A., Fotopoulou, C., Gonzalez-Martin, A., Colombo, N., Sessa, C., et al. Nitipir C, Parosanu A, Popa AM, Cotan H, Olaru M, Iaciu C, Orlov Slavu C. Cureus. doi: 10.1200/JOP.18.00761. Unable to load your collection due to an error, Unable to load your delegates due to an error.
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